Adjusting the focus on γ-secretase inhibition
نویسندگان
چکیده
منابع مشابه
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
A hallmark of Alzheimer's disease (AD) pathology is the accumulation of brain amyloid β-peptide (Aβ), generated by γ-secretase-mediated cleavage of the amyloid precursor protein (APP). Therefore, γ-secretase inhibitors (GSIs) may lower brain Aβ and offer a potential new approach to treat AD. As γ-secretase also cleaves Notch proteins, GSIs can have undesirable effects due to interference with N...
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Presenilins (PS) are the catalytic components of gamma-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the gamma-secretase-dependent cleavage of the beta-amyloid precursor protein (APP) since generates the beta-amyloid (Abeta) peptides that aggregate and accumulate in the brain of Alzheimer's diseas...
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Platelets are formed by budding of cyto-plasm from megakaryocytes in the bone marrow. Although the splicing machinery is localized in the nucleus of megakaryocyte precursor cells, splicing factors begin to accumulate in the cytoplasm of mature mega-karyocytes. The splicing components together with specific partially spliced pre-mRNAs are included in the forming anucleate platelets. Upon stimula...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2019
ISSN: 1474-175X,1474-1768
DOI: 10.1038/s41568-019-0174-0